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ML 355
- Soluble in DMSO
- MF: C21H19N3O4S2
- MW: 441.52
Description
Potent inhibitor of 12-lipoxygenase (12-LOX) (IC50 value of 0.34 µM) which shows excellent selectivity against related enzymes (15-LOX-1, 5-LOX, 15-LOX-2, COX-1/-2). Besides, ML 355 exhibits a favourable in vitro ADME and in vivo PK profile with activity in disease relevant cell-based systems, such thrombosis (platelet aggregation and calcium mobilization), and diabetes (12-HETE reducing in β -cells).
More Information
| Parent CAS No. | 1532593-30-8 |
|---|---|
| Chemical Name | N-(Benzo[d]thiazol-2-yl)-4-(2-hydroxy-3-methoxybenzylamino)benzenesulfonamide |
| SMILES | C1C2N=C(NS(C3C=CC(NCC4C=CC=C(OC)C=4O)=CC=3)(=O)=O)SC=2C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H19N3O4S2/c1-28-18-7-4-5-14(20(18)25)13-22-15-9-11-16(12-10-15)30(26,27)24-21-23-17-6-2-3-8-19(17)29-21/h2-12,22,25H,13H2,1H3,(H,23,24) |
| InChiKey | OWHBVKBNNRYMIN-UHFFFAOYSA-N |
| CID | 70701426 |
| Short Description | Lipoxygenase inhibitor |
References
- D Luci et al. Discovery of ML355, a Potent and Selective Inhibitor of Human 12-Lipoxygenase. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2013 Apr 12.
- DK Luci et al. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem. 2014 Jan 23;57(2):495-506.
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