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FLI 06
Axon 2277
CAS:
313967-18-9
Purity:
100%
- Soluble in DMSO
- MF: C25H30N2O5
- MW: 438.52
Description
Notch signaling inhibitor (EC50 value 2.3 μM) that acts early in the secretory pathway. Although the precise molecular target of FLI 06 remains unclear, it effects a unique property to inhibit cargo recruitment to ER exit sites (ERESs) by changing its curvature. Consequently, it inhibits the membrane traffic of NotchΔE-eGFP at pre-ERES stages without fusion of ER-Golgi.FLI 06 does not inhibit the γ-secretase mediated proteolytical processing of NotchΔE-eGFP to NICD-eGFP at the plasma membrane.
More Information
| Parent CAS No. | 313967-18-9 |
|---|---|
| Chemical Name | cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate |
| SMILES | C1(C)NC2CC(C)(C)CC(=O)C=2C(C2C=CC([N+]([O-])=O)=CC=2)C=1C(OC1CCCCC1)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28/h9-12,18,22,26H,4-8,13-14H2,1-3H3 |
| InChiKey | SWWVFYHSSOWZMF-UHFFFAOYSA-N |
| CID | 3103157 |
| Short Description | Notch signaling inhibitor |
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