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AVE0991
- Soluble in DMSO
- MF: C29H32N4O5S2
- MW: 580.72
Description
AVE0991, a non-peptide Ang-(1-7) mimetic, is a selective and orally active Mas receptor agonist (IC50 value of 21 nM).
More Information
| Parent CAS No. | 304462-19-9 |
|---|---|
| Chemical Name | N-(Ethylcarbamoyl)-3-(4-((5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl)phenyl)-5-isobutylthiophene-2-sulfonamide |
| SMILES | C1(CN2C(C3C=CC=CC=3)=NC(OC)=C2C=O)C=CC(C2=C(S(=O)(=O)NC(NCC)=O)SC(CC(C)C)=C2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C29H32N4O5S2/c1-5-30-29(35)32-40(36,37)28-24(16-23(39-28)15-19(2)3)21-13-11-20(12-14-21)17-33-25(18-34)27(38-4)31-26(33)22-9-7-6-8-10-22/h6-14,16,18-19H,5,15,17H2,1-4H3,(H2,30,32,35) |
| InChiKey | QTOZBSNPDCWHPV-UHFFFAOYSA-N |
| CID | 9851724 |
| Short Description | Mas agonist |
References
- G Wiemer et al. AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium. Hypertension. 2002 Dec;40(6):847-52.
- DS Skiba et al. Anti-atherosclerotic effect of the angiotensin 1-7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis. Br J Pharmacol. 2017 Nov;174(22):4055-4069.
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