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CID 1067700

 - ML282
Axon 2184
CAS:  314042-01-8
Purity:  99%
  • Soluble in DMSO
  • MF:  C18H18N2O4S2
  • MW:  390.48

Description

First inhibitor of Rab7 GTPase exhibiting significant inhibitory potency on Rab7 nucleotide binding with nanomolar inhibitor (Ki) values and an inhibitory response of ≥97% for BODIPY-GTP and BODIPYGDP binding (Ki values 13 nM and 19 nM, and EC50 values 11 and 21 nM, respectively). CID 1067700 is a competitive guanine nucleotide binding inhibitor characterized for the Ras-super family of GTPases.

More Information

Parent CAS No. 314042-01-8
Chemical Name 2-(3-benzoylthioureido)-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid
SMILES C1OC(C)(C)CC2C(C(O)=O)=C(NC(NC(=O)C3=CC=CC=C3)=S)SC1=2
MFCD N.A.
InChi InChI=1S/C18H18N2O4S2/c1-18(2)8-11-12(9-24-18)26-15(13(11)16(22)23)20-17(25)19-14(21)10-6-4-3-5-7-10/h3-7H,8-9H2,1-2H3,(H,22,23)(H2,19,20,21,25)
InChiKey ATSWBWHRHAQVFM-UHFFFAOYSA-N
CID 1067700
Short Description Rab7 GTPase inhibitor

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