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TUG 891
Axon 2075
CAS:
1374516-07-0
Purity:
99%
- Soluble in DMSO
- MF: C23H21FO3
- MW: 364.41
Description
Potent and selective agonist for G-protein coupled receptor 120 (GPR120), also known as the free fatty acid receptor FFA4 (EC50: 44 and 17 nM for human GPR120 and mouse GPR120 respectively
More Information
| Parent CAS No. | 1374516-07-0 |
|---|---|
| Chemical Name | 3-(4-((4-fluoro-4'-methylbiphenyl-2-yl)methoxy)phenyl)propanoic acid |
| SMILES | C1(CCC(O)=O)=CC=C(OCC2=CC(F)=CC=C2C2=CC=C(C)C=C2)C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H21FO3/c1-16-2-7-18(8-3-16)22-12-9-20(24)14-19(22)15-27-21-10-4-17(5-11-21)6-13-23(25)26/h2-5,7-12,14H,6,13,15H2,1H3,(H,25,26) |
| InChiKey | LPGBXHWIQNZEJB-UHFFFAOYSA-N |
| CID | 57522038 |
| Short Description | GPR120 agonist |
References
- DE Jorenby et al. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA 2006, 296 (1), 56–63.
- RS Obach et al. Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro. Drug Metab Dispos 2006, 34, 121-30.
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