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REP 3123 dihydrochloride
- CRS3123 dihydrochloride
- Parent CAS: 1013915-71-3 (absolute, (+)-rotamer)
- Optical Purity: >98% e.e.
- Soluble in DMSO
- MF: C19H19Br2N3O2S.2HCl
- MW: 586.17
Description
Selective inhibitor of methionyl-tRNA synthetase (MetRS); agent to treat Clostridium difficile infection (CDI); Antibiotic.
More Information
| Parent CAS No. | 1013915-71-3 (absolute, (+)-rotamer) |
|---|---|
| Chemical Name | (R)-5-(3-(6,8-dibromochroman-4-ylamino)propylamino)thieno[3,2-b]pyridin-7(4H)-one dihydrochloride |
| SMILES | C1(Br)C2OCC[C@@H](NCCCNC3=CC(=O)C4SC=CC=4N3)C=2C=C(Br)C=1.Cl.Cl |&1:6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C19H19Br2N3O2S.2ClH/c20-11-8-12-14(2-6-26-18(12)13(21)9-11)22-4-1-5-23-17-10-16(25)19-15(24-17)3-7-27-19;;/h3,7-10,14,22H,1-2,4-6H2,(H2,23,24,25);2*1H/t14-;;/m1../s1 |
| InChiKey | HZJABMYSJSDCBO-FMOMHUKBSA-N |
| CID | 24762985 |
| Short Description | MetRS inhibitor |
References
- UA Ochsner et al. Inhibitory effect of REP3123 on toxin and spore formation in Clostridium difficile, and in vivo efficacy in a hamster gastrointestinal infection model. J. Antimicrob. Chemother. 2009, 63(5), 964-971.
- IA Critchley et al. Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections. J. Antimicrob. Chemother. 2009, 63(5), 954-963.
- DM Citron et al. Comparative in vitro activity of REP3123 against Clostridium difficile and other anaerobic intestinal bacteria. J. Antimicrob. Chemother. 2009, 63(5), 972-976.
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