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NVP-TAE684
- TAE 684
- Soluble in DMSO
- MF: C30H40ClN7O3S
- MW: 614.2
Description
Potent, selective and efficacious inhibitor of NPM-ALK.
More Information
| Parent CAS No. | 761439-42-3 |
|---|---|
| Chemical Name | 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-pyperidinyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-Pyrimidinediamine |
| SMILES | C1(N2CCC(N3CCN(C)CC3)CC2)C=C(OC)C(NC2N=C(NC3C(S(=O)(=O)C(C)C)=CC=CC=3)C(Cl)=CN=2)=CC=1 |
| MFCD | MFCD11977634 |
| InChi | InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35) |
| InChiKey | QQWUGDVOUVUTOY-UHFFFAOYSA-N |
| CID | 16038120 |
| Short Description | ALK inhibitor |
References
- AV Galkin et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc. Natl. Acad. Sci. USA 2007, 104 (1), 270-275.
- U McDermott et al. Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors. Cancer Res. 2008, 68(9), 3389-3395.
- K van Roosbroeck et al. ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions. Haematologica. 2010, 95, 509-513.
- List of publications using NVP-TAE684 (Axon 1416) purchased from Axon Medchem
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