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PF 5274857 hydrochloride
- PF 05274857 hydrochloride
Axon 2027
CAS:
1373615-35-0
Purity:
99%
- Soluble in water and DMSO
- MF: C20H25ClN4O3S.HCl
- MW: 473.42
Description
Potent and selective smoothened (SMO) antagonist with Ki value of 4.6 nM; a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway
More Information
| Parent CAS No. | 1373615-35-0 |
|---|---|
| Chemical Name | 1-(4-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one hydrochloride |
| extra_info | . |
| SMILES | C(N1CCN(C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2)CC1)(=O)CCS(C)(=O)=O.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C20H25ClN4O3S.ClH/c1-14-10-15(2)20(23-12-14)16-11-18(22-13-17(16)21)24-5-7-25(8-6-24)19(26)4-9-29(3,27)28;/h10-13H,4-9H2,1-3H3;1H |
| InChiKey | GULNFUQAVPTTQV-UHFFFAOYSA-N |
| CID | 90489027 |
| Short Description | SMO antagonist |
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