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PF 477736
- PF 00477736
Axon 1379
CAS:
952021-60-2
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C22H25N7O2
- MW: 419.48
Description
Chk1 inhibitor with Ki values of 0.49 and 47 nM for Chk1 and Chk2 respectively. A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity
More Information
| Parent CAS No. | 952021-60-2 |
|---|---|
| Chemical Name | (R)-2-Amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-acetamide |
| extra_info | . |
| SMILES | N1C(=O)C2C=C(NC(=O)[C@H](N)C3CCCCC3)C=C3NC(C4C=NN(C)C=4)=C(C=23)C=N1 |&1:9,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15)16)26-22(31)19(23)12-5-3-2-4-6-12/h7-12,19,27H,2-6,23H2,1H3,(H,26,31)(H,28,30)/t19-/m1/s1 |
| InChiKey | NDEXUOWTGYUVGA-LJQANCHMSA-N |
| CID | 135565545 |
| Short Description | CHK1 inhibitor |
References
- JW Janetka et al, Inhibitors of Checkpoint Kinases: From discovery to the clinic. Curr. Opin. Drug Discov. & Devel. 2007, 10(4), 473-486.
- S. Ashwell and S Zabludoff. DNA Damage Detection and Repair Pathways Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy. Clin. Cancer Res. 2008, 14(13), 4033-4037.
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