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TC11
- CLT-003
- Soluble in DMSO
- MF: C20H22N2O2
- MW: 322.4
Description
TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. TC11 also showed in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. Nucleophosmin 1 (NPM/B23) was identified as a target of TC11 for inducing apoptosis of tumor cells. Moreover, TC11 induces disruption of tubulin polymerization leading to mitotic arrest and promotes degradation of anti-apoptotic protein, MCL1, by sustained CDK1 activation.
More Information
| Parent CAS No. | 100823-03-8 |
|---|---|
| Chemical Name | 5-Amino-2-(2,6-diisopropylphenyl)isoindoline-1,3-dione |
| SMILES | C1(N)C=C2C(=O)N(C3C(C(C)C)=CC=CC=3C(C)C)C(=O)C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H22N2O2/c1-11(2)14-6-5-7-15(12(3)4)18(14)22-19(23)16-9-8-13(21)10-17(16)20(22)24/h5-12H,21H2,1-4H3 |
| InChiKey | NRPIRIUWEKTNGQ-UHFFFAOYSA-N |
| CID | 1235479 |
| Short Description | Apoptosis inducer |
References
- D Ichikawa et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020 Jan 1;521(1):252-258.
- H Shiheido et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS One. 2012;7(6):e38878.
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