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Finasteride
- MK-906
Axon 3240
CAS:
98319-26-7
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C23H36N2O2
- MW: 372.54
Description
Finasteride is a potent, reversible inhibitor of the rat type 1 5α-reductase with a Ki value of 10.2 nM. Finasteride has been shown to reduce the size of human benign prostatic hyperplasia (BPH) by inhibiting the intraprostatic conversion of testosterone to 5 alpha-dihydrotestosterone.
More Information
| Parent CAS No. | 98319-26-7 |
|---|---|
| Chemical Name | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-tert-Butyl-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide |
| SMILES | C1=C[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H](C(NC(C)(C)C)=O)CC[C@@]4([H])[C@]3([H])CC[C@@]2([H])NC1=O |&1:2,4,8,10,20,22,26,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1 |
| InChiKey | DBEPLOCGEIEOCV-WSBQPABSSA-N |
| CID | 57363 |
| Short Description | 5α-reductase inhibitor |
References
- JR Carlin et al. High-performance liquid chromatographic determination of N-(2-methyl-2-propyl)-3-oxo-4-aza-5 alpha-androst-1-ene-17 beta-carboxamide, a 4-azasteroid, in human plasma from a phase I study. J Chromatogr. 1988 May 13;427(1):79-91.
- B Azzolina et al. Inhibition of rat alpha-reductases by finasteride: evidence for isozyme differences in the mechanism of inhibition. J Steroid Biochem Mol Biol. 1997 Apr;61(1-2):55-64.
- H Weisser et al. 5 alpha-reductase inhibition by finasteride (Proscar) in epithelium and stroma of human benign prostatic hyperplasia. Steroids. 1994 Nov;59(11):616-20.
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