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APPA

Axon 2883
CAS:  100750-39-8
Purity:  99%
  • Soluble in DMSO
  • MF:  C14H13NO3
  • MW:  243.26

Description

APPA is an aldose reductase inhibitor with an IC50 value of 0.0223 μM. APPA could inhibit apoptosis in rat glomerular mesangial cells in vitro. In addition, APPA improved the pathological symptoms of streptozotocin-induced diabetic nephropathy (DN) in rats by affecting antioxidant activities and reducing the levels of TGF-β, collagen IV, and laminin.

More Information

Parent CAS No. 100750-39-8
Chemical Name 1-Acetyl-5-phenyl-1H-pyrrol-3-yl acetate
SMILES C1C=C(C2N(C(C)=O)C=C(OC(=O)C)C=2)C=CC=1
MFCD N.A.
InChi InChI=1S/C14H13NO3/c1-10(16)15-9-13(18-11(2)17)8-14(15)12-6-4-3-5-7-12/h3-9H,1-2H3
InChiKey WKSITCBIIIHVSF-UHFFFAOYSA-N
CID 13785326
Short Description Aldose reductase inhibitor

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