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SBI-425
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C13H12ClN3O4S
- MW: 341.77
Description
SBI-425 is a potent, selective and oral bioavailable inhibitor of tissue-nonspecific alkaline phosphatase (TNAP) with an IC50 value of 0.016 μM. SBI-425 robustly inhibits TNAP in vivo after oral dosing. Furthermore, SBI-425 demonstrated activity in blocking calcification in patient derived fibroblasts as well as in rodent models of GACI and PXE.
More Information
| Parent CAS No. | 1451272-71-1 |
|---|---|
| Chemical Name | 5-(5-Chloro-2-methoxyphenylsulfonamido)nicotinamide |
| SMILES | C1C(Cl)=CC(S(NC2C=C(C(=O)N)C=NC=2)(=O)=O)=C(OC)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C13H12ClN3O4S/c1-21-11-3-2-9(14)5-12(11)22(19,20)17-10-4-8(13(15)18)6-16-7-10/h2-7,17H,1H3,(H2,15,18) |
| InChiKey | SBAITEDLNTYIOE-UHFFFAOYSA-N |
| CID | 89768286 |
| Short Description | TNAP inhibitor |
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