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JK184
- Soluble in DMSO and EtOH
- MF: C19H18N4OS
- MW: 350.44
Description
Antagonist of Hedgehog (Hh) signaling (IC50 value of 30 nM for inhibition of Gli-dependent transcriptional activity) and a potent inhibitor of microtubule assembly that exhibits good antiproliferative activity both in vitro and in vivo. JK184 appears to act by inhibition of Adh7 (Kd value 210 nM in a assay for enzymatic oxidation of retinol).
More Information
| Parent CAS No. | 315703-52-7 |
|---|---|
| Chemical Name | N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine |
| SMILES | S1C=C(C2N3C(=NC=2C)C=CC=C3)N=C1NC1=CC=C(OCC)C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22) |
| InChiKey | ROYXIPOUVGDTAO-UHFFFAOYSA-N |
| CID | 1069686 |
| Short Description | Hedgehog inhibitor |
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