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SBI-810

Axon 4405
CAS:  1849603-79-7
Purity:  99%
  • Soluble in 0.1N HCl(aq), DMSO and EtOH
  • MF:  C27H34N4O2
  • MW:  446.59

Description

SBI-810 is a β-arrestin biased, orally bioavailable, and CNS-penetrant Neurotensin Receptor 1 (NTR1) allosteric modulator. SBI-810 can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and also mitigate opioid withdrawal effects.

Key Features

  • β-arrestin biased NTR1 allosteric modulator
  • Orally bioavailable compound
  • CNS penetrant
  • Reduces acute and chronic pain in rodent models
  • Mitigates opioid withdrawal effects

Applications

  • NTR1 and neurotensin signaling research
  • Pain and analgesia studies
  • Biased GPCR signaling investigations
  • Opioid withdrawal and addiction research
  • Central nervous system pharmacology studies

More Information

Parent CAS No. 1849603-79-7
Chemical Name 2-((4-(4-(2-Methoxyphenyl)-1-piperidyl)-2-(1-methylcyclopropyl)-6-quinazolinyl)-N-methylamino)ethanol
SMILES C1=C2N=C(C3(C)CC3)N=C(N3CCC(C4=CC=CC=C4OC)CC3)C2=CC(N(C)CCO)=C1
InChi InChI=1S/C27H34N4O2/c1-27(12-13-27)26-28-23-9-8-20(30(2)16-17-32)18-22(23)25(29-26)31-14-10-19(11-15-31)21-6-4-5-7-24(21)33-3/h4-9,18-19,32H,10-17H2,1-3H3
InChiKey TVMPWGASZCIMMZ-UHFFFAOYSA-N
CID 155510650
Short Description NTR1 allosteric modulator

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