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Sorafenib
- BAY 43-9006 - Nexavar
- Soluble in DMSO
- MF: C21H16ClF3N4O3
- MW: 464.82
Description
Small molecule inhibitor of protein kinase, targeting the Raf/Mek/Erk pathway.
The tosylate salt of Sorafenib is available as Axon 1397.
More Information
| Parent CAS No. | 284461-73-0 |
|---|---|
| Chemical Name | 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide |
| SMILES | N1C=CC(OC2C=CC(NC(=O)NC3C=C(C(F)(F)F)C(Cl)=CC=3)=CC=2)=CC=1C(=O)NC |
| MFCD | MFCD06411450 |
| InChi | InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) |
| InChiKey | MLDQJTXFUGDVEO-UHFFFAOYSA-N |
| CID | 216239 |
| Short Description | Raf inhibitor |
References
- SM Wilhelm et al. BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis. Cancer Res. 2004, 64, 7099-7109.
- SM Wilhelm et al. The novel Raf inhibitor Bay 43-9006 blocks signaling and proliferation in BRAF mutant and wildtype melanoma and colorectal tumor cell lines. Proc. Am. Assoc. Cancer Res. 2003, 44, 106609.
- S. S. Sridhar et al. Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther. 2005, 4, 677-685.
- S. S. Sridhar et al. Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther. 2005, 4, 677-685.
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