Bulk Inquiry
KDU691
Axon 2845
CAS:
1513879-19-0
Purity:
99%
- Soluble in DMSO
- MF: C22H18ClN5O2
- MW: 419.86
Description
KDU691 is a plasmodium PI4K inhibitor (IC50 values of 0.18 μM and 0.061 μM against hypnozoite forms and liver schizontsm, respectively) which selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites. Moreover, KDU691 was fully protective when administered in vivo as causal prophylactic and radical-cure agents for Plasmodium cynomolgi sporozoite-infected rhesus macaques.
More Information
| Parent CAS No. | 1513879-19-0 |
|---|---|
| Chemical Name | N-(4-Chlorophenyl)-N-methyl-3-(4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide |
| SMILES | C1C=C(N(C)C(=O)C2N=CC3=NC=C(C4C=CC(C(NC)=O)=CC=4)N3C=2)C=CC=1Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C22H18ClN5O2/c1-24-21(29)15-5-3-14(4-6-15)19-11-26-20-12-25-18(13-28(19)20)22(30)27(2)17-9-7-16(23)8-10-17/h3-13H,1-2H3,(H,24,29) |
| InChiKey | TYMFFISSODJRDV-UHFFFAOYSA-N |
| CID | 90157166 |
| Short Description | PI4K inhibitor |
References
- AM Zeeman et al. PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2858-63.
- L Dembele et al. The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites. Sci Rep. 2017 May 24;7(1):2325.
Other Categories
Get a Quote for
Loading...