KU-0058948

Based on 20 reference(s) in Google Scholar 8 10 20

Axon 4179

CAS [763111-49-5]

MF C21H21FN4O2
MW 380.42

Purity: 99%
Soluble in 0.1N HCl(aq), DMSO and EtOH

Recently added

KU-0058948

Description

Potent and specific PARP inhibitor (IC50: 3.4 nM for PARP1); KU-0058948 activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells and induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro. The hydrochloride salt form, KU-0058948 hydrochloride (Axon 2001) is also available.

Keywords: KU-0058948 | Supplier | PARP1 inhibitor | KU0058948 | KU 0058948 | CAS [763111-49-5] | [2108829-86-1] | [1379676-61-5] | DNA-RNA | PARP | Inhibitor | Enzymes

H Farmer et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005, 434, 917-921.

K Ratnam and JA Low. Current Development of Clinical Inhibitors of Poly(ADP-Ribose) Polymerase in Oncology. Clin. Cancer Res. 2007, 13, 1383.

NC Turner et al. A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. EMBO J. 2008, 27, 1368-1377.

T Hay et al. Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. Cancer Res. 2009, 69(9), 3850.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 2.4.2.30 PARP

Potent and specific PARP1 inhibitor

Chemical name

4-(3-(1,4-Diazepane-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

Parent CAS No.

[763111-49-5]

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Size	Unit Price	Stock
10 mg	€135.00	In Stock
50 mg	€505.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 10 mg	€220.00	In Stock
2 x 50 mg	€760.00	In Stock

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1529	AG 014699	PARP1 inhibitor	€60.00
1566	Iniparib	PARP inhibitor	€60.00
1593	Veliparib	PARP inhibitor	€40.00
2001	KU-0058948 hydrochloride	Potent and specific PARP1 inhibitor	€135.00
2241	AZD2461	PARP inhibitor with poor P-glycoprotein substrate qualities	€95.00
2369	UPF 1069	PARP-2 inhibitor with >26 fold selectivity over PARP1	€75.00

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