KU-0058948 hydrochloride

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2001

CAS [2108829-86-1]

MF C21H21FN4O2.HCl
MW 416.88

Purity: 99%
Soluble in water and DMSO

KU-0058948 hydrochloride

Description

Potent and specific PARP inhibitor (IC50: 3.4 nM for PARP1); KU-0058948 activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells and induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro. The freebase, KU-0058948 (Axon 4179) is also available.

KEYWORDS: KU-0058948 hydrochloride | supplier | PARP1 inhibitor | KU-58948 | KU0058948 | KU58948 | KU 0058948 | KU 058948 | CAS [763111-49-5] | [2108829-86-1] | DNA-RNA | PARP | ERK8 | extracellular signal-regulated kinase 8 | cell cycle arrest | apoptosis | repair | Poly(ADP-Ribose) Polymerase

H Farmer et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005, 434, 917-921.

K Ratnam and JA Low. Current Development of Clinical Inhibitors of Poly(ADP-Ribose) Polymerase in Oncology. Clin. Cancer Res. 2007, 13, 1383.

NC Turner et al. A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. EMBO J. 2008, 27, 1368-1377.

T Hay et al. Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. Cancer Res. 2009, 69(9), 3850.

List of publications using KU 0058948 HCl (Axon 2001) purchased from Axon Medchem

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 2.4.2.30 PARP

Potent and specific PARP1 inhibitor

Chemical name

4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one hydrochloride

Parent CAS No.

[763111-49-5]

Order

Size	Unit Price	Stock
10 mg	€135.00	In Stock
50 mg	€505.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 10 mg	€220.00	In Stock
2 x 50 mg	€760.00	In Stock

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KU-0058948 hydrochloride

Description

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