2,5-Dimethylcelecoxib - DMC

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2496

CAS [457639-26-8]

MF C18H16F3N3O2S
MW 395.40

Purity: 100%
Soluble in DMSO

2,5-Dimethylcelecoxib

Description

Celecoxib analog that lacks COX-2 inhibitory activity but exhibits anti-tumor properties; DMC reduced growth and initiated apoptotic cell death in several MM cell lines. Mechanistically, DMC down-regulates critical components of the cell-cycle machinery (cyclins A and B); blocks the activity of important mitogenic and survival pathways (MEK, NF-κB, STAT3, survivin); and leads to increased caspase activity. Moreover, DMC quite potently mimics the ability of celecoxib to stimulate the endoplasmic reticulum stress response (ESR) and subsequent cell death .

A. Kardosh et al. Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib. Blood. 2005 Dec 15;106(13):4330-8.

A. Kardosh et al. Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo. Cancer Biol Ther. 2005 May;4(5):571-82.

P. Pyrko et al. Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib. Mol Cancer Ther. 2007 Apr;6(4):1262-75.

Angiogenesis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology NF-κB MAPK JAK-STAT Apoptosis inducer

Celecoxib analog with anti-tumor properties, lacking COX-2 inhibitory activity

Chemical name

4-(5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Parent CAS No.

[457639-26-8]

Order

Size	Unit Price	Stock
10 mg	€75.00	In Stock
50 mg	€225.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1772	CDDO-Me	IKK-2 inhibitor; Inducer of the Nrf2 pathway	€80.00
1827	IMS 2186	Apoptosis inducer. Inhibitor of PGE2/TNF-α production	€95.00
1950	CDDO	A potent multifunctional anti-tumor agent. PPAR-γ agonist	€80.00
1963	LY 573636	Anti-tumor agent; causes growth arrest and apoptosis	€80.00
2326	Temozolomide	DNA methylating agent; apoptosis inducer	€50.00
2327	NEO 212	DNA alkylating agent; chemotherapeutic	€110.00
3745	Elesclomol	Apoptosis inducer	€90.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

2,5-Dimethylcelecoxib - DMC

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

2,5-Dimethylcelecoxib - DMC

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us