Apoptosis inducer

The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis occurs normally during development and aging and as a homeostatic mechanism to maintain cell populations in tissues. It is considered a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death.
The alternative to apoptotic cell death is necrosis, which is considered to be a toxic process where the cell is a passive victim and follows an energy-independent mode of death. But since necrosis refers to the degradative processes that occur after cell death, it is considered by some to be an inappropriate term to describe a mechanism of cell death.
Using conventional histology, it is not always easy to distinguish apoptosis from necrosis, and they can occur simultaneously depending on factors such as the intensity and duration of the stimulus, the extent of ATP depletion and the availability of caspases. Necrosis is an uncontrolled and passive process that usually affects large fields of cells whereas apoptosis is controlled and energy-dependent and can affect individual or clusters of cells[1].

[1] S. Elmore. Apoptosis: a review of programmed cell death. Toxicol. Pathol. 2007, 35, 495-516.

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Axon ID Name Description From price
2496 2,5-Dimethylcelecoxib Celecoxib analog with anti-tumor properties, lacking COX-2 inhibitory activity €75.00
N0007 Benastatin A Glutathione S-Transferase (GST) π class inhibitor, anti-MRSA Inquire
N0008 Benastatin B Glutathione S-Transferase (GST) π class inhibitor, anti-MRSA Inquire
N0009 Benastatin C Glutathione S-Transferase (GST) π Class Inhibitor, activities on the murine lymphocyte blastogenesis. Inquire
2431 Chloroquine diphosphate Classical antimalarial drug causing necrosis and apoptosis €40.00
3970 CNDAC hydrochloride Induces DNA damage and apoptosis. €145.00
N0014 COMC Inhibits the proliferation of B16 murine melanoma cells Inquire
3825 Cordycepin Nucleoside analogue; Anticancer and anti-inflammatory agent €60.00
3459 Dacarbazine DNA alkylating agent; antineoplastic agent €50.00
3745 Elesclomol Apoptosis inducer €90.00
4149 Everolimus Selective and orally active mTOR1 inhibitor Inquire
2432 Hydroxychloroquine sulfate Antimalarial drug with immunosuppressive and anti-inflammatory effects €60.00
1827 IMS 2186 Apoptosis inducer. Inhibitor of PGE2/TNF-α production €95.00
2327 NEO 212 DNA alkylating agent; chemotherapeutic €110.00
4045 Nimustine hydrochloride Water-soluble DNA alkylating agent €90.00
3826 NUC-7738 Prodrug of Cordycepin; Anticancer agent €160.00
2627 SMER 28 Small molecule enhancer of rapamycin that enhances autophagy €80.00
2894 STF 62247 Inducer of apoptosis and autophagy in VHL-deficient RCC cells €85.00
3149 TC11 Anti-tumor agent; Apoptosis inducer €110.00
2326 Temozolomide DNA methylating agent; apoptosis inducer €50.00

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