MAO

MAO

Mono-amine oxidases (MAO; EC 1.4.3.x) play an important role in neurotransmitter metabolism. Inhibitors of this class of enzymes have played a major role in our understanding of the functional roles of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) neurotransmission in the CNS. However, due to their potentially lethal dietary and drug interactions (“cheese effect”), monoamine oxidase inhibitors have historically been reserved as a last-in-line treatment of psychiatric disorders, only to be used when other classes of antidepressant drugs have failed.

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More About MAO

Mono-amine oxidases (MAO; EC 1.4.3.x) play an important role in neurotransmitter metabolism. Inhibitors of this class of enzymes have played a major role in our understanding of the functional roles of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) neurotransmission in the CNS. However, due to their potentially lethal dietary and drug interactions (“cheese effect”), monoamine oxidase inhibitors have historically been reserved as a last-in-line treatment of psychiatric disorders, only to be used when other classes of antidepressant drugs have failed[1].

[1] http://www.mayoclinic.com/health/depression/DS00175/DSECTION=treatments-and-drugs

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