P-O Lyases

Soluble guanylate cyclase (sGC; EC, a heme-containing heterodimer, is the only proven receptor for the gaseous ligand NO and plays a crucial role in the NO/cGMP signaling pathway and downstream functional effects, e.g., vasorelaxation, platelet aggregation, or neurotransmission. Activation of the enzyme by NO leads to a five coordinated heme–nitrosyl complex, and facilitates conversion of GTP to the intracellular second messenger cGMP. It is this latter molecule cGMP, which mediates the majority of biological actions attributed to NO. sGC is expressed in virtually all mammalian cells and is important in mediating numerous physiological processes, including vascular and non-vascular smooth muscle relaxation, peripheral and central neurotransmission, platelet reactivity and phototransduction[1].

[1] A.J. Hobbs et al. Soluble guanylate cyclase. Exp. Opin. Ther. Targets 2000, 4, 735–749

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  1. LRE1


    Starting at: €95.00

    Allosteric sAC inhibitor Learn More
  2. Forskolin


    Starting at: €90.00

    Adenylate cyclase activator Learn More
  3. BAY 58-2667 hydrochloride

    BAY 58-2667 hydrochloride

    Starting at: €125.00

    sGC activator Learn More

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