P-O Lyases

Soluble guanylate cyclase (sGC; EC 4.6.1.2), a heme-containing heterodimer, is the only proven receptor for the gaseous ligand NO and plays a crucial role in the NO/cGMP signaling pathway and downstream functional effects, e.g., vasorelaxation, platelet aggregation, or neurotransmission. Activation of the enzyme by NO leads to a five coordinated heme–nitrosyl complex, and facilitates conversion of GTP to the intracellular second messenger cGMP. It is this latter molecule cGMP, which mediates the majority of biological actions attributed to NO. sGC is expressed in virtually all mammalian cells and is important in mediating numerous physiological processes, including vascular and non-vascular smooth muscle relaxation, peripheral and central neurotransmission, platelet reactivity and phototransduction[1].


[1] A.J. Hobbs et al. Soluble guanylate cyclase. Exp. Opin. Ther. Targets 2000, 4, 735–749

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Axon ID Name Description From price
2172 BAY 58-2667 hydrochloride Soluble, potent nitric oxide-independent guanylyl cyclase (sGC) activator €125.00
2264 Forskolin Activator of adenylate cyclase. Naturally occurring labdane diterpene €90.00
2664 LRE1 Allosteric soluble adenylyl cyclase (sAC) inhibitor €95.00

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