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LRE1

 - RU-0204277
Axon 2664
CAS:  1252362-53-0
Purity:  98%
  • Soluble in DMSO
  • MF:  C12H13ClN4S
  • MW:  280.78

Description

LRE1 (RU-0204277) is a potent, allosteric inhibitor specific to soluble adenylyl cyclase (sAC), exhibiting an IC50 value ≤ 10 μM. It functions by occupying the binding pocket of the physiological activator bicarbonate HCO3-, effectively blocking downstream sAC-dependent cellular and physiological processes. In sAC-overexpressing cellular assays, LRE1 effectively suppresses cAMP accumulation with an IC50 value of 11 μM.

Given the critical relevance of sAC pharmacology to translational disease research, LRE1 serves as an ideal tool for driving mechanistic studies of sAC across diverse biochemical, cellular, and animal model assays.

Key Features

  • Allosteric sAC inhibitor that competes directly with the physiological activator bicarbonate
  • Targets sAC over transmembrane adenylyl cyclases (tmACs)
  • Modulates sAC-dependent signaling and biological activity
  • Demonstrates excellent cellular tolerability and safety in living systems

Applications

  • sAC pharmacology and target-validation studies
  • sAC pathway and signaling assays
  • Disease-relevant cellular and translational model systems
  • Compound profiling, assay development and lead-optimization support

More Information

Parent CAS No. 1252362-53-0
Chemical Name 6-Chloro-N4-cyclopropyl-N4-(thiophen-2-ylmethyl)pyrimidine-2,4-diamine
SMILES N1C(N)=NC(N(C2CC2)CC2SC=CC=2)=CC=1Cl
MFCD MFCD23148480
InChi InChI=1S/C12H13ClN4S/c13-10-6-11(16-12(14)15-10)17(8-3-4-8)7-9-2-1-5-18-9/h1-2,5-6,8H,3-4,7H2,(H2,14,15,16)
InChiKey PDWZXKSZLRVSEH-UHFFFAOYSA-N
CID 47279808
Short Description Allosteric sAC inhibitor

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