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Forskolin
- Coleonol
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C22H34O7
- MW: 410.5
Description
Forskolin is a potent adenylate cyclase activator with an IC50 value of 41 nM. This naturally occurring labdane diterpene directly activates adenylate cyclase, leading to increased intracellular cAMP levels and stimulation of cAMP-dependent physiological responses.
Forskolin has been extensively used as a research tool to study cAMP-mediated signaling pathways. Elevation of cAMP levels by Forskolin induces neuronal differentiation of mesenchymal stem cells through activation of the ERK/MAPK signaling pathway. In addition, Forskolin exhibits antihypertensive and vasodilatory activity, supporting its use in cardiovascular and cell signaling research.
Key Features
- Potent adenylate cyclase activator
- IC50: 41 nM
- Directly increases intracellular cAMP levels
- Activates cAMP-dependent signaling pathways
- Induces neuronal differentiation via ERK/MAPK activation
- Naturally occurring labdane diterpene
Applications
- cAMP signaling pathway research
- Adenylate cyclase biology studies
- Stem cell differentiation research
- Neuronal differentiation studies
- ERK/MAPK signaling research
- Cardiovascular and vasodilation studies
More Information
| Parent CAS No. | 66575-29-9 |
|---|---|
| Chemical Name | (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate |
| SMILES | [C@@]12(C)[C@@H](OC(C)=O)[C@@H](O)[C@]3([H])[C@@](C)([C@@]1(O)C(=O)C[C@@](C=C)(C)O2)[C@@H](O)CCC3(C)C |&1:0,2,7,9,11,13,18,23,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1 |
| InChiKey | OHCQJHSOBUTRHG-KGGHGJDLSA-N |
| CID | 47936 |
| Short Description | Adenylate cyclase activator |
References
- A. Laurenza et al. Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action? Trends Pharmacol Sci. 1989, 10, 442-447.
- S.S. Kim et al. cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK. Neuroreport. 2005, 16, 1357-1361.
- K. Seamon et al. Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J. Med. Chem., 1983, 26, 436–439.
- J.D. Robbins et al. Forskolin carbamates: binding and activation studies with type I adenylyl cyclase. J. Med. Chem. 1996, 39, 2745-2752.
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