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Zagociguat
- CY6463 - IW6463
Axon 4307
CAS:
2201048-82-8
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C16H10F4N6
- MW: 362.29
Description
Zagociguat is a first potent brain-penetrant soluble guanylate cyclase (sGC) stimulator with EC50 values of 66 nM (GloSensor luciferase assay) and 46 nM (cGMP assay of rat primary neurons). Zagociguat improved neuronal activity, mediated neuroprotection, and increased cognitive performance in preclinical models.
More Information
| Parent CAS No. | 2201048-82-8 |
|---|---|
| Chemical Name | 5-(7-((2-Fluorophenyl)methyl)-1,3a-diaza-5-indenyl)-3-(trifluoromethyl)-1H-1,2,4-triazole |
| SMILES | C12=NC=CN1C=C(C1NN=C(C(F)(F)F)N=1)N=C2CC1C(F)=CC=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H10F4N6/c17-10-4-2-1-3-9(10)7-11-14-21-5-6-26(14)8-12(22-11)13-23-15(25-24-13)16(18,19)20/h1-6,8H,7H2,(H,23,24,25) |
| InChiKey | GTKNNCQKFKGSHR-UHFFFAOYSA-N |
| CID | 134304734 |
| Short Description | sGC stimulator |
References
- SS Correia et al. The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases. Front Pharmacol. 2021 May 24;12:656561.
- SJW van Kraaij et al. First-in-human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS-penetrant soluble guanylyl cyclase stimulator. Clin Transl Sci. 2023 Aug;16(8):1381-1395.
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