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Iclepertin - BI425809

Based on 10 reference(s) in Google Scholar 8 10 10

Axon 4201

CAS [1421936-85-7]

MF C20H18F6N2O5S
MW 512.42

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in DMSO and EtOH
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Iclepertin

Description

Iclepertin is a potent, selective and orally active glycine transporter 1 (GlyT-1) inhibitor with IC50 values of 5.2 nM and 5.0 nM in rat primary neurons and human SK-N-MC cells, respectively. In addition, no activity of Iclepertin against the related glycine transporter, GlyT-2, was demonstrated nor against other off-targets.

KEYWORDS: Iclepertin | Supplier | GlyT-1 inhibitor | BI425809 | B-I425809 | BI 425809 | CAS [1421936-85-7] | Glycine | Inhibitor

Potent, selective and orally active GlyT-1 inhibitor

Chemical name

(5-(Methylsulfonyl)-2-((R)-1,1,1-trifluoropropan-2-yloxy)phenyl)((1R,5R)-1-(5-(trifluoromethyl)isoxazol-3-yl)-3-azabicyclo[3.1.0]hexan-3-yl)methanone

Parent CAS No.

[1421936-85-7]

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Size Unit Price Stock
5 mg €240.00 In Stock
25 mg €960.00 In Stock
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Related Products

Axon ID Name Description From price
1238 ALX 5407 hydrochloride GlyT-1 inhibitor €140.00
1549 SSR 504734 GlyT-1 inhibitor €110.00
1563 ORG 25935 GlyT-1 inhibitor €90.00

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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