AOH1996 is an orally administrable and metabolically stable PCNA inhibitor which suppresses tumor growth as a monotherapy or as a combination treatment but causes no discernable side effects. AOH1996 enhances the interaction between PCNA and the largest subunit of RNA polymerase II, RPB1, and dissociates PCNA from actively transcribed chromatin regions, while inducing DNA double-stranded breaks in a transcription-dependent manner.

Keywords: AOH1996 | Supplier | PCNA inhibitor | AOH 1996 | AOH-1996 | CAS [2089314-64-5] | DNA-RNA | DNA | Inhibitor | Enzymes