Alantolactone

Based on 406 reference(s) in Google Scholar 8 10 406

Axon 3834

CAS [546-43-0]

MF C15H20O2
MW 232.32

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

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Alantolactone

Description

Alantolactone is a STAT3 inhibitor which completely suppressed inducible and constitutively activated STAT3 and blocked the nuclear translocation and the DNA-binding activity of STAT3 in MDA-MB-231 cells. Also, Alantolactone inhibited activity of NLRP3 inflammasomes by directly targeting the NACHT domain of NLRP3.

J Chun et al. Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Cancer Lett. 2015 Feb 1;357(1):393-403.

W Li et al. Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3-driven inflammatory diseases in mice. Br J Pharmacol. 2023 Jan 20.

Apoptosis Cell Signaling & Oncology Epigenetics Pain & Inflammation Transcription Factors TF class 4.2.1 STAT3

STAT3 inhibitor; NLRP3 inhibitor

Chemical name

(3aR,5S,8aR,9aR)-5,8a-Dimethyl-3-methylene-3,3a,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(5H)-one

Parent CAS No.

[546-43-0]

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Size	Unit Price	Stock
10 mg	€90.00	In Stock
50 mg	€310.00	In Stock

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