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ABT-639
Axon 3785
CAS:
1235560-28-7
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C20H20ClF2N3O3S
- MW: 455.91
Description
ABT-639 is a peripherally acting, selective and orally bioavailable T-type Ca2+ channel blocker. ABT-639 blocks recombinant human T-type (Ca(v)3.2) Ca2+ channels in a voltage-dependent fashion (IC50 value of 2 μM) and attenuates LVA currents in rat DRG neurons (IC50 value of 8 μM).
More Information
| Parent CAS No. | 1235560-28-7 |
|---|---|
| Chemical Name | (R)-4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide |
| SMILES | C1[C@@]2([H])CCCN2CCN1C(=O)C1C(Cl)=CC(F)=C(S(=O)(=O)NC2C(F)=CC=CC=2)C=1 |&1:1,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C20H20ClF2N3O3S/c21-15-11-17(23)19(30(28,29)24-18-6-2-1-5-16(18)22)10-14(15)20(27)26-9-8-25-7-3-4-13(25)12-26/h1-2,5-6,10-11,13,24H,3-4,7-9,12H2/t13-/m1/s1 |
| InChiKey | AGPIHNZOZNKRGT-CYBMUJFWSA-N |
| CID | 46851313 |
| Short Description | Ca channel blocker |
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