AMG-176 - Tapotoclax

Based on 7 reference(s) in Google Scholar 8 10 7

Axon 3686

CAS [1883727-34-1]

MF C33H41ClN2O5S
MW 613.21

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO

AMG-176

Description

AMG 176 (Tapotoclax) is an orally bioavailable, highly potent and selective Mcl-1 inhibitor, binding reversibly to BH3- groove of the protein with a Ki value in picomolar range. Demonstrate in vitro and in vivo antitumor efficacy in Mcl-1 dependent cancer models. It is currently in clinical evaluation for the treatment of hematologic malignancies.

* Sold in collaboration with Chemietek.

KEYWORDS: AMG-176 | Mcl-1 inhibitor | Tapotoclax | AMG 176 | AMG176 | CT-AMG176 | CAS [1883727-34-1] | Non Selective | Mcl-1 | Inhibitor | Proteins

Potent and selective Mcl-1 inhibitor

Chemical name

(3'R,4S,6'R,7'S,8'E,11'S,12'R)-7-chloro-7'-methoxy-11',12'-dimethyl-13',13'-dioxospiro[2,3-dihydro-1H-naphthalene-4,22'-20-oxa-13λ6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16(25),17,19(24)-tetraene]-15'-one

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1883727-34-1]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...