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Tafamidis
- Soluble in DMSO
- MF: C14H7Cl2NO3
- MW: 308.12
Description
Tafamids is a small-molecule inhibitor that binds selectively to the transthyretin (TTR) protein in human plasma and kinetically stabilizes the tetrameric structure of both wild-type TTR and a number of different mutants. Tafamidis is an oral medication for treating cardiomyopathy and peripheral neuropathy due to transthyretin amyloidosis (ATTR). It is a transthyretin stabilizer and has been shown to reduce disease progression and mortality significantly.
More Information
| Parent CAS No. | 594839-88-0 |
|---|---|
| Chemical Name | 2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid |
| SMILES | C1(C(=O)O)C=C2OC(C3C=C(Cl)C=C(Cl)C=3)=NC2=CC=1 |
| MFCD | MFCD16621109 |
| InChi | InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19) |
| InChiKey | TXEIIPDJKFWEEC-UHFFFAOYSA-N |
| CID | 11001318 |
| Short Description | Selective TTR stabilizer |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 4021 | Tafamidis meglumine |
From $88.00 |
| 4107 | PITB |
From $143.00 |
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