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PITB
Axon 4107
CAS:
3054913-44-6
Purity:
98%
- Soluble in DMSO and EtOH
- MF: C14H10FNO6
- MW: 307.23
Description
PITB is a high affinity, orally bioavailable transthyretin (TTR) aggregation inhibitor with optimal pharmacokinetic properties. PITB binds with high affinity to TTR, effectively inhibiting tetramer dissociation and aggregation of both the wild-type protein and the two most prevalent disease-associated TTR variants.
More Information
| Parent CAS No. | 3054913-44-6 |
|---|---|
| Chemical Name | (3-Fluoro-5-hydroxyphenyl)(4-hydroxy-3-methoxy-5-nitrophenyl)methanone |
| SMILES | C1(OC)C=C(C(=O)C2C=C(F)C=C(O)C=2)C=C([N+]([O-])=O)C=1O |
| MFCD | N.A. |
| InChi | InChI=1S/C14H10FNO6/c1-22-12-5-8(4-11(14(12)19)16(20)21)13(18)7-2-9(15)6-10(17)3-7/h2-6,17,19H,1H3 |
| InChiKey | LHCGDAFIWWCKGM-UHFFFAOYSA-N |
| CID | 169450070 |
| Short Description | TTR aggregation inhibitor |
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