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MS1943 trifluoroacetate

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3469

CAS [N.A.]

MF C42H54N8O3.2CF3CO2H
MW 946.98

  • Purity: 98%
  • Soluble in DMSO and EtOH

MS1943 trifluoroacetate

Description

MS1943 trifluoroacetate is a first-in-class EZH2 selective degrader that effectively reduces EZH2 levels in cells. MS1943 has a profound cytotoxic effect in multiple TNBC cells, while sparing normal cells, and is efficacious in vivo, suggesting that pharmacologic degradation of EZH2 can be advantageous for treating the cancers that are dependent on EZH2.

KEYWORDS: MS1943 trifluoroacetate | EZH2 degrader | MS 1943 | MS-1943 | CAS [2225938-18-9] | [2225938-17-8] | Histone | HMTase | Degrader | Enzymes | Triple-negative breast cancer | TNBC | PROTAC | Hydrophobic tagging technology

First-in-class EZH2 selective degrader; PROTAC

Chemical name

6-[6-[4-[2-[[2-(1-Adamantyl)acetyl]amino]ethyl]piperazin-1-yl]pyridin-3-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-ylindazole-4-carboxamide trifluoroacetate

Parent CAS No.

[2225938-17-8]

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5 mg €200.00 In Stock
25 mg €700.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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