Bulk Inquiry
Floxuridine
- 5-Fluorodeoxyuridine - FdUrd
Axon 3462
CAS:
50-91-9
- Optical Purity: Optically pure
- Soluble in water, DMSO and EtOH
- MF: C9H11FN2O5
- MW: 246.19
Description
Floxuridine is an antimetabolite and a thymidylate synthetase inhibitor.
More Information
| Parent CAS No. | 50-91-9 |
|---|---|
| Chemical Name | 5-Fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| SMILES | [C@@H]1(O)[C@@H](CO)O[C@@H](N2C=C(F)C(=O)NC2=O)C1 |&1:0,2,6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 |
| InChiKey | ODKNJVUHOIMIIZ-RRKCRQDMSA-N |
| CID | 5790 |
| Short Description | TYMS inhibitor |
References
- AR Bapat et al. Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J Biol Chem. 1983 Apr 10;258(7):4130-6.
- AM Huehls et al. Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. Cancer Res. 2011 Jul 15;71(14):4944-54.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 2853 | Nolatrexed dihydrochloride |
From $132.00 |
| 3162 | Pemetrexed disodium |
From $55.00 |
| 3233 | Gemcitabine hydrochloride |
From $55.00 |
| 3238 | Cytarabine |
From $55.00 |
| 3253 | 6-Thioguanine |
From $44.00 |
| 3460 | Capecitabine |
From $55.00 |
| 4279 | TAS-102 |
From $99.00 |
Other Categories
Get a Quote for
Loading...
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.