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Nolatrexed dihydrochloride
- AG 337 - Thymitaq
Axon 2853
- Parent CAS: 147149-76-6
Purity:
98%
- Soluble in water and DMSO
- MF: C14H12N4OS.2HCl
- MW: 357.26
Description
Nolatrexed dihydrochloride is a water soluble, lipophilic inhibitor of thymidylate synthase (Ki value of 11 nM). Nolatrexed dihydrochloride displayed non-competitive inhibition kinetics and was shown to inhibit cell growth in a panel of cell lines of murine and human origin (IC50 values between 0.39 and 6.6 µM).
More Information
| Parent CAS No. | 147149-76-6 |
|---|---|
| Chemical Name | 2-Amino-6-methyl-5-(pyridin-4-ylthio)quinazolin-4(3H)-one dihydrochloride |
| SMILES | N1C(=O)C2C(SC3C=CN=CC=3)=C(C)C=CC=2N=C1N.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H |
| InChiKey | PJKVJJYMWOCLIJ-UHFFFAOYSA-N |
| CID | 135409535 |
| Short Description | Thymidylate synthase inhibitor |
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