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ODM-207
- Soluble in DMSO
- MF: C22H21N3O3
- MW: 375.42
Description
ODM-207 is a highly potent, selective and orally active pan-BET inhibitor that has shown preclinical evidence of tumour growth inhibition in breast cancer and in leukaemia and prostate cancer xenograft models.
More Information
| Parent CAS No. | 1801503-93-4 |
|---|---|
| Chemical Name | 6-(3,5-Dimethylisoxazol-4-yl)-7-methoxy-3-methyl-1-(pyridin-2-ylmethyl)quinolin-2(1H)-one |
| SMILES | C1(OC)C=C2N(CC3N=CC=CC=3)C(=O)C(C)=CC2=CC=1C1C(C)=NOC=1C |
| MFCD | N.A. |
| InChi | InChI=1S/C22H21N3O3/c1-13-9-16-10-18(21-14(2)24-28-15(21)3)20(27-4)11-19(16)25(22(13)26)12-17-7-5-6-8-23-17/h5-11H,12H2,1-4H3 |
| InChiKey | YVGWSVHZXWFLIT-UHFFFAOYSA-N |
| CID | 118224658 |
| Short Description | BET inhibitor |
References
- M Björkman et al. Abstract 4649: ODM-207, a novel BET-bromodomain inhibitor as a therapeutic approach for the treatment of prostate and breast cancer. Cancer Res. 76, 4649 (2016).
- M Ameratunga et al. First-in-human Phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours. Br J Cancer. 2020 Sep 29.
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