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DCZ0415
Axon 3216
CAS:
2242470-43-3
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C23H20N2O2
- MW: 356.42
Description
DCZ0415 is an AAA-ATPase TRIP13 inhibitor with a Kd value of 2.42 μM. DCZ0415 induced antimyeloma activity in vitro (IC50 values of 1.0-10 μM in multiple myeloma cell lines), in vivo, and in primary cells derived from drug-resistant patients with myeloma. Moreover, DCZ0415 impaired nonhomologous end joining repair and inhibited NF-κB activity.
More Information
| Parent CAS No. | 2242470-43-3 |
|---|---|
| Chemical Name | 4-[4-(Pyridin-4-ylmethyl)phenyl]-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene-3,5-dione |
| SMILES | C12C3C4CC4C(C1C(=O)N(C1C=CC(CC4C=CN=CC=4)=CC=1)C2=O)C=C3 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H20N2O2/c26-22-20-16-5-6-17(19-12-18(16)19)21(20)23(27)25(22)15-3-1-13(2-4-15)11-14-7-9-24-10-8-14/h1-10,16-21H,11-12H2 |
| InChiKey | LOXMLWHUIONWMI-UHFFFAOYSA-N |
| CID | 145925662 |
| Short Description | TRIP13 inhibitor |
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