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Apcin
- Soluble in DMSO
- MF: C13H14Cl3N7O4
- MW: 438.65
Description
Apcin is an inhibitor of APC/C-Cdc20. Apcin binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates. Apcin causes either net APC/C inhibition, prolonging mitosis when spindle assembly checkpoint (SAC) activity is low, or net APC/C activation, shortening mitosis when SAC activity is high.
More Information
| Parent CAS No. | 300815-04-7 |
|---|---|
| Chemical Name | 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl 2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethylcarbamate |
| SMILES | N1C=CC=NC=1NC(C(Cl)(Cl)Cl)NC(=O)OCCN1C(C)=NC=C1[N+]([O-])=O |
| MFCD | N.A. |
| InChi | InChI=1S/C13H14Cl3N7O4/c1-8-19-7-9(23(25)26)22(8)5-6-27-12(24)21-10(13(14,15)16)20-11-17-3-2-4-18-11/h2-4,7,10H,5-6H2,1H3,(H,21,24)(H,17,18,20) |
| InChiKey | ZEXHXVOGJFGTRX-UHFFFAOYSA-N |
| CID | 2830389 |
| Short Description | APC/C-Cdc20 inhibitor |
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