(+)-Blebbistatin

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3144

CAS [1177356-70-5]

MF C18H16N2O2
MW 292.33

Purity: 99%
Optical purity: 99.5% e.e.
Soluble in DMSO

(+)-Blebbistatin

Description

(+)-Blebbistatin is the inactive enantiomer of (±)-Blebbistatin (Axon 2718) with an IC50 value of >100 μM for ATPase activity; Negative control for non-muscle myosin II studies. The active enantiomer (-)-Blebbistatin is available as Axon 3074.

C Lucas-Lopez et al. Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (-)-Blebbistatin. European Journal of Organic Chemistry (2005), (9), 1736-1740.

S Verhasselt et al. Discovery of (S)-3'-hydroxyblebbistatin and (S)-3'-aminoblebbistatin: polar myosin II inhibitors with superior research tool properties. Org Biomol Chem. 2017;15(9):2104–2118.

Negative control of (±)-Blebbistatin as an inhibitor of class II myosins

Chemical name

(R)-3a-Hydroxy-6-methyl-1-phenyl-3,3a-dihydro-1H-pyrrolo[2,3-b]quinolin-4(2H)-one

Parent CAS No.

[1177356-70-5]

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Size	Unit Price	Stock
2 mg	€90.00	In Stock
5 mg	€150.00	In Stock

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Related Products

Axon ID	Name	Description
1835	CK 1827452	Cardiac specific myosin ATPase activator	€115.00
2683	MYK-461	Cardiac specific myosin ATPase inhibitor	€135.00
2718	(±)-Blebbistatin	Potent and specific inhibitor of class II myosins	€95.00
3074	(-)-Blebbistatin	Selective inhibitor of class II myosins; Active enantiomer of (±)-Blebbistatin	€90.00

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(+)-Blebbistatin

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(+)-Blebbistatin

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