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Aficamten
- CK274 - CK3773274
Axon 4000
CAS:
2364554-48-1
- Optical Purity: 100% e.e.
- Soluble in DMSO and EtOH
- MF: C18H19N5O2
- MW: 337.38
Description
Aficamten is a next-in-class cardiac myosin inhibitor with an IC50 value of 1.4 μM.
More Information
| Parent CAS No. | 2364554-48-1 |
|---|---|
| Chemical Name | (R)-N-(5-(5-Ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide |
| SMILES | C1C=C2[C@H](NC(C3=CN(C)N=C3)=O)CCC2=CC=1C1=NOC(CC)=N1 |&1:3,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C18H19N5O2/c1-3-16-21-17(22-25-16)12-4-6-14-11(8-12)5-7-15(14)20-18(24)13-9-19-23(2)10-13/h4,6,8-10,15H,3,5,7H2,1-2H3,(H,20,24)/t15-/m1/s1 |
| InChiKey | IOVAZWDIRCRMTM-OAHLLOKOSA-N |
| CID | 139331495 |
| Short Description | Myosin inhibitor |
References
- C Chuang et al. Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy. J Med Chem. 2021 Oct 14;64(19):14142-14152.
- AN Sharpe et al. Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy. Sci Rep. 2023 Jan 2;13(1):32.
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