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AZD6738
- Ceralasertib
Axon 3134
CAS:
1352226-88-0
- Optical Purity: 98% e.e.
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C20H24N6O2S
- MW: 412.51
Description
AZD6738 is a potent, selective, orally active and bioavailable ATR kinase inhibitor with an IC50 value of 0.001 µM against the isolated enzyme and 0.074 µM against ATR kinase-dependent CHK1 phosphorylation in cells.
More Information
| Parent CAS No. | 1352226-88-0 |
|---|---|
| Chemical Name | (R)-3-Methyl-4-(6-(1-((R)-S-methylsulfonimidoyl)cyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)morpholine |
| SMILES | C1C(N2CCOC[C@H]2C)=NC(C2C3C=CNC=3N=CC=2)=NC=1C1(CC1)[S@](=N)(=O)C |&1:7,25,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C20H24N6O2S/c1-13-12-28-10-9-26(13)17-11-16(20(5-6-20)29(2,21)27)24-19(25-17)15-4-8-23-18-14(15)3-7-22-18/h3-4,7-8,11,13,21H,5-6,9-10,12H2,1-2H3,(H,22,23)/t13-,29-/m1/s1 |
| InChiKey | OHUHVTCQTUDPIJ-JYCIKRDWSA-N |
| CID | 54761306 |
| Short Description | ATR inhibitor |
References
- KM Foote et al. Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent. J Med Chem. 2018;61(22):9889‐9907.
- FP Vendetti et al. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo. Oncotarget. 2015;6(42):44289-44305.
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