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BRD0539
- Optical Purity: 99% e.e.
- Soluble in DMSO and EtOH
- MF: C25H25FN2O3S
- MW: 452.54
Description
BRD0539 is a reversible and cell-permeable inhibitor of SpCas9 with an apparent IC50 value of 22 μM (in vitro DNA cleavage assay).
More Information
| Parent CAS No. | 1403838-79-8 |
|---|---|
| Chemical Name | ((3aR,4R,9bR)-8-(2-Fluorophenyl)-1-tosyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-4-yl)methanol |
| SMILES | C1C=C(F)C(C2C=C3[C@@H]4N(S(C5C=CC(C)=CC=5)(=O)=O)CC[C@@H]4[C@H](CO)NC3=CC=2)=CC=1 |&1:8,22,23,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C25H25FN2O3S/c1-16-6-9-18(10-7-16)32(30,31)28-13-12-20-24(15-29)27-23-11-8-17(14-21(23)25(20)28)19-4-2-3-5-22(19)26/h2-11,14,20,24-25,27,29H,12-13,15H2,1H3/t20-,24+,25-/m1/s1 |
| InChiKey | CZOIXFMISSBIJL-DCEDVJGZSA-N |
| CID | 54666326 |
| Short Description | Cas9 inhibitor |
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