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RS-1
- RAD51-Stimulatory Compound-1
Axon 2584
CAS:
312756-74-4
Purity:
99%
- Soluble in DMSO
- MF: C20H16Br2N2O3S
- MW: 524.23
Description
Enhancer of CRISPR-based genome editing and homology-directed repair (HDR; RAD51). RS-1 can enhance filament stability, and stimulated hRAD51-mediated homologous strand assimilation (D-loop) activity by at least 5- to 11-fold. RS-1 acts as an allosteric regulator that locks hRAD51 in an active conformation and does so without influencing the active site for ATP hydrolysis. Treatment with RS-1 promoted significant antitumor responses in a mouse model.
More Information
| Parent CAS No. | 312756-74-4 |
|---|---|
| Chemical Name | 3-(N-benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide |
| SMILES | C(NC1=CC=C(Br)C=C1)(=O)C1=CC=C(Br)C(S(NCC2=CC=CC=C2)(=O)=O)=C1 |
| MFCD | MFCD00348720 |
| InChi | InChI=1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25) |
| InChiKey | SWKAVEUTKGKHSR-UHFFFAOYSA-N |
| CID | 1039737 |
| Short Description | RAD51 stimulator |
References
- K Jayathilaka et al. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15848-53.
- J Song et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat Commun. 2016 Jan 28;7:10548.
- J Pinder et al. Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing. Nucleic Acids Res. 2015 Oct 30;43(19):9379-92.
- JM Mason et al. The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors. Cancer Res. 2014 Jul 1;74(13):3546-55.
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