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RAD51 inhibitor B02
Axon 1911
CAS:
1290541-46-6
Purity:
98%
- Soluble in DMSO
- MF: C22H17N3O
- MW: 339.39
Description
RAD51 inhibitor B02 is a specific and cell-permeable RAD51 inhibitor that inhibits the DNA strand-exchange activity of human RAD51 with a reported IC50 value of 27.4 μM.
RAD51 is essential for homologous recombination repair of double-strand DNA breaks. RAD51 inhibitor B02 disrupts RAD51 binding to DNA and increases cellular sensitivity to DNA damage, making it useful for DNA repair and synthetic-lethality research.
Key Features
- Cell-permeable RAD51 inhibitor
- IC50: 27.4 μM for human RAD51 strand-exchange activity
- Disrupts RAD51 binding to DNA
- Sensitizes cells to DNA damage
Applications
- Homologous recombination repair studies
- RAD51 biochemical and cellular assays
- DNA damage sensitization experiments
- Cancer synthetic-lethality model research
More Information
| Parent CAS No. | 1290541-46-6 |
|---|---|
| Chemical Name | (E)-3-benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one |
| SMILES | N1C2=C(C=CC=C2)C(=O)N(CC2=CC=CC=C2)C=1/C=C/C1=CC=CN=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+ |
| InChiKey | GEKDQXSPTHHANP-OUKQBFOZSA-N |
| CID | 5738263 |
| Short Description | RAD51 inhibitor |
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