ATR-101 is a potent, selective and orally efficacious acyl coenzyme A:cholesterol acyltransferase isoform 1 (ACAT1) inhibitor (IC50 value of 0.009 µM). ATR-101 potently lowers plasma total cholesterol in various animal models of hypercholesterolemia but is an adrenal toxicant. Furthermore, ATR-101 inhibits cholesterol efflux and cortisol secretion by ATP-binding cassette transporters, causing cytotoxic cholesterol accumulation in ACC cells.

KEYWORDS: ATR-101 | supplier | ACAT inhibitor | PD132301-2 | Nevanimibe hydrochloride | ATR101 | ATR 101 | PD-132301-2 | PD 132301-2 | CAS [133825-81-7] | [133825-80-6] | Cholesterol | ACAT | Inhibitor | Enzymes | Adrenocortical carcinoma | Congenital adrenal hyperplasia | Cushing's syndrome