ATR-101 - PD 132301-2 | Nevanimibe hydrochloride

Based on 26 reference(s) in Google Scholar 8 10 26

Axon 2960

CAS [133825-81-7]

MF C27H39N3O.HCl
MW 458.08

  • Purity: 98%
  • Soluble in DMSO
Recently added

ATR-101

Description

ATR-101 is a potent, selective and orally efficacious acyl coenzyme A:cholesterol acyltransferase isoform 1 (ACAT1) inhibitor (IC50 value of 0.009 µM). ATR-101 potently lowers plasma total cholesterol in various animal models of hypercholesterolemia but is an adrenal toxicant. Furthermore, ATR-101 inhibits cholesterol efflux and cortisol secretion by ATP-binding cassette transporters, causing cytotoxic cholesterol accumulation in ACC cells.

KEYWORDS: ATR-101 | supplier | ACAT inhibitor | PD 132301-2 | Nevanimibe hydrochloride | ATR101 | ATR 101 | PD132301-2 | CAS [133825-81-7] | [133825-80-6] | Cholesterol | ACAT | Inhibitor | Enzymes | Adrenocortical carcinoma | Congenital adrenal hyperplasia | Cushing's syndrome

Order
Size Unit Price Stock
10 mg €145.00 In Stock
50 mg €545.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...