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AZD0780

 - Laroprovstat
Axon 4259
CAS:  2455427-91-3
  • Optical Purity:  100% e.e.
  • Soluble in DMSO and EtOH
  • MF:  C20H20F2N6O2
  • MW:  414.41

Description

AZD0780 is an orally active PCSK9 inhibitor with a Kd value of <200 nM. AZD0780 inhibits lysosomal trafficking of PSCK9-LDLR complexes and prevents PCSK9-induced LDLR degradation.

More Information

Parent CAS No. 2455427-91-3
Chemical Name 1-(6-((1S,3S)-3-(5-(Difluoromethoxy)pyrimidin-2-ylamino)cyclopentylamino)pyridin-3-yl)pyridin-2(1H)-one
SMILES C1(N[C@@H]2C[C@@H](NC3N=CC(OC(F)F)=CN=3)CC2)C=CC(N2C(=O)C=CC=C2)=CN=1 |&1:2,4,r|
MFCD N.A.
InChi InChI=1S/C20H20F2N6O2/c21-19(22)30-16-11-24-20(25-12-16)27-14-5-4-13(9-14)26-17-7-6-15(10-23-17)28-8-2-1-3-18(28)29/h1-3,6-8,10-14,19H,4-5,9H2,(H,23,26)(H,24,25,27)/t13-,14-/m0/s1
InChiKey NCHUWRLOTSAFFN-KBPBESRZSA-N
CID 154653847
Short Description PCSK9 inhibitor

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