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Lomitapide

 - BMS 201038  - AEGR-733
Axon 2917
CAS:  182431-12-5
Purity:  98%
  • Soluble in DMSO
  • MF:  C39H37F6N3O2
  • MW:  693.72

Description

Lomitapide is a highly potent microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 value of 0.5 nM. Moreover, lomitapide inhibited the production of lipoprotein particles in rodent models and normalized plasma lipoprotein levels in Watanabe-heritable hyperlipidemic (WHHL) rabbits, which are a model for human homozygous familial hypercholesterolemia.

More Information

Parent CAS No. 182431-12-5
Chemical Name N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)biphenyl-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide
SMILES N1(CCCCC2(C(NCC(F)(F)F)=O)C3C=CC=CC=3C3C=CC=CC2=3)CCC(NC(=O)C2C(C3C=CC(C(F)(F)F)=CC=3)=CC=CC=2)CC1
MFCD MFCD16620494
InChi InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
InChiKey MBBCVAKAJPKAKM-UHFFFAOYSA-N
CID 9853053
Short Description MTP inhibitor

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