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Enzymes
Transferases
Kinases (Serine-Threonine Specific Protein)
MAP3K
Selonsertib

Selonsertib - GS 4997

Based on 6 reference(s) in Google Scholar 8 10 6

Axon 2956

CAS [1448428-04-3]

MF C24H24FN7O
MW 445.49

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

Selonsertib

Description

Selonsertib is a potent, highly selective, orally available, and ATP-competitive ASK1 inhibitor with a pIC50 value of 8.3.

KEYWORDS: Selonsertib | supplier | ASK1 inhibitor | GS 4997 | GS4997 | GS-4997 | CAS [1448428-04-3] | [1448428-05-4] | MAPK | MAP3K | Inhibitor | Enzymes | Diabetic nephropathy | Kidney fibrosis

JH Lin et al. Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33.

M Lanier et al. Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure. ACS Med Chem Lett. 2017 Feb 8;8(3):316-320.

Apoptosis Cell Signaling & Oncology MAPK EC 2.7.11.35 MAP3K

Potent, highly selective, orally available, and ATP-competitive ASK1 inhibitor

Chemical name

5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide

Parent CAS No.

[1448428-04-3]

Order

Size	Unit Price	Stock
10 mg	€90.00	In Stock
50 mg	€270.00	In Stock

Need more? Bulk Inquiry

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