4-IBP is a selective sigma-1 (σ-1) agonist with Ki values of 1.70 nM and 25.2 nM for σ-1 and σ-2 receptor subtypes, respectively. Activating the σ-1 receptor with noncytotoxic doses of 4-IBP decreases the migration levels of various types of cancer cells, including C32 melanoma, U373-MG glioblastoma, A549 NSCLC, and PC3 prostate cancer cells. Moreover, 4-IBP sensitizes these cancer cells in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs.

KEYWORDS: 4-IBP | supplier | Sigma-1 agonist | NSC 667672 | 4IBP | 4 IBP | NSC667672 | NSC-667672 | CAS [155798-08-6] | Sigma Receptor Substrates | Sigma-1 | Agonist | Receptors